Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking.
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More
Citations
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Muscolini, M; Sajeva, A; et al. A novel association between filamin A and NF-kappa B inducing kinase couples CD28 to inhibitor of NF-kappa B kinase alpha and NF-kappa B activation. IMMUNOLOGY LETTERS 136:203-212(2011).
Ohashi, K; Oshima, K; et al. Chicken gizzard filamin, retina filamin and cgABP260 are respectively, smooth muscle-, non-muscle- and pan-muscle-type isoforms: Distribution and localization in muscles. CELL MOTILITY AND THE CYTOSKELETON 61:214-225(2005).
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