Anti-FLNA monoclonal antibody, clone 5F21-2C3

Antibody Isotype

IgG1

Clone

5F21-2C3

Species Reactivity

Human

Immunogen

Recombinant full length protein, corresponding to amino acids 1-839 of Human Filamin A with Propietary tag (AAH14654).

Conjugate

Application Notes

WB: 1/500 - 1/1000; IHC-P: 5 μg/ml;

Alternative Names

FLNA; filamin A, alpha; filamin A, alpha (actin binding protein 280) , FLN, FLN1, OPD1, OPD2; filamin-A; ABP 280; actin binding protein 280; filamin-1; alpha-filamin; non-muscle filamin; endothelial actin-binding protein; FLN; FMD; MNS; OPD; ABPX; CVD1; F

Entrez Gene ID

UniProt ID

Antigen Description

Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking.

Pathway

Androgen Receptor Signaling Pathway, organism-specific biosystem; Cell junction organization, organism-specific biosystem; Cell-Cell communication, organism-specific biosystem; Cell-extracellular matrix interactions, organism-specific biosystem; Focal Adhesion, organism-specific biosystem; Focal adhesion, organism-specific biosystem; Focal adhesion, conserved biosystem;