Mouse anti-Human FKBP38 polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Recombinant full length protein corresponding to amino acids 1-413 of Human FKBP38 (NP_036313.3).

Conjugate

Alternative Names

FKBP8; FK506 binding protein 8, 38kDa; FKBP38; FKBPr38; peptidyl-prolyl cis-trans isomerase FKBP8; FKBP-8; FKBP-38; hFKBP38; rotamase; 38 kDa FKBP; PPIase FKBP8; 38 kDa FK506-binding protein; FK506-binding protein 8 (38kD);

Entrez Gene ID

UniProt ID

Antigen Description

Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis.

Pathway

Role of Calcineurin-dependent NFAT signaling in lymphocytes;