Anti-FKBP8 monoclonal antibody (DCABH-2164) Knockout Validated

Rabbit anti-Human FKBP8 monoclonal antibody for WB, FC, ICC/IF

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Clone
FQS8552(3)
Species Reactivity
Human
Immunogen
Synthetic peptide corresponding to N-terminal amino acids of Human FKBP38.
Conjugate
Unconjugated

Applications


Application Notes
WB: 1/1000 - 1/10000; Flow Cyt: 1/10 - 1/100; ICC/IF: 1/100 - 1/250.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
FKBP8; FK506 binding protein 8, 38kDa; FK506 binding protein 8 (38kD); peptidyl-prolyl cis-trans isomerase FKBP8; FKBP38; FKBPr38
Entrez Gene ID
UniProt ID

Product Background


Gene summary
FKBP8 (FK506 Binding Protein 8) is a Protein Coding gene. Diseases associated with FKBP8 include hepatitis c virus. Among its related pathways are Role of Calcineurin-dependent NFAT signaling in lymphocytes and Senescence and Autophagy. GO annotations related to this gene include identical protein binding and FK506 binding. The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. Unlike the other members of the family, this encoded protein does not seem to have PPIase/rotamase activity. It may have a role in neurons associated with memory function.
Antigen Description
Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis. FK506-binding protein 8 is a protein that in humans is encoded by the FKBP8 gene. 0The function about FKBP8 antigen include FK506 binding; isomerase activity; peptidyl-prolyl cis-trans isomerase activity; protein binding.
Pathway
Role of Calcineurin-dependent NFAT signaling in lymphocytes, organism-specific biosystem.

Citations


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References


Tani, J; Shimamoto, S; et al. Ca2+/S100 proteins regulate HCV virus NS5A-FKBP8/FKBP38 interaction and HCV virus RNA replication. LIVER INTERNATIONAL 33:1008-1018(2013).

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