Anti-FKBP4 monoclonal antibody, clone FQS7729

Antibody Isotype

IgG

Clone

FQS7729

Species Reactivity

Mouse; Rat; Human

Immunogen

Synthetic peptide corresponding to residues in Human FKBP52.

Conjugate

Application Notes

WB: 1/1000 - 1/10000; IHC-P: 1/250 - 1/500; Flow Cyt: 1/10 - 1/100; ICC/IF: 1/50 - 1/100.

Alternative Names

FKBP4; FK506 binding protein 4, 59kDa; FK506 binding protein 4 (59kD); peptidyl-prolyl cis-trans isomerase FKBP4; FKBP52; FKBP59; rotamase; HSP binding immunophilin; 51 kDa FK506-binding protein; FK506-binding protein 4 (59kD); T-cell FK506-binding protei

Entrez Gene ID

UniProt ID

Antigen Description

Immunophilin protein with PPIase and co-chaperone activities (By similarity). Component of unliganded steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments (By similarity). The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly.

Pathway

Coregulation of Androgen receptor activity, organism-specific biosystem; Glucocorticoid receptor regulatory network, organism-specific biosystem;