Anti-FGFR1 (mutation V664L) Monoclonal Antibody, clone XH059

Clone

XH059

Species Reactivity

Human

Immunogen

A synthetic peptide from the internal region of FGFR1 which includes the mutation of V664L, human origin.

Conjugate

Application Notes

ELISA: 1:1000-1:2000
WB: 1:500-1:1000
IHC: 1:50-1:100

Entrez Gene ID

Antigen Description

The protein FGFR1 is highly conserved between members and throughout evolution. This particular family member of FGFR1 binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations of FGFR1 protein have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, squamous cell lung cancer and autosomal dominant Kallmann syndrome.

Pathway

Adaptive Immune System; Adherens junction; Axon guidance; Central carbon metabolism in cancer; Constitutive Signaling by Aberrant PI3K in Cancer;