Promotes the formation of filopodia. May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape.
Pathway
Cell death signalling via NRAGE, NRIF and NADE; G alpha (12/13) signalling events; GPCR downstream signaling; NRAGE signals death through JNK; Regulation of actin cytoskeleton; Rho GTPase cycle;
Citations
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