Specifications
Species Reactivity
Mouse; Rat; Human
Immunogen
Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human FGD3 aa 100-200 (Cysteine residue). The exact sequence is proprietary.Database link: Q5JSP0
Applications
Application Notes
WB: 1/1000 - 1/10000; ICC/IF: 1/50 - 1/100; Flow Cyt: 1/10 - 1/100.
Target
Alternative Names
FGD3; FYVE, RhoGEF and PH domain containing 3; FGD1 family, member 3; FYVE, RhoGEF and PH domain-containing protein 3; FLJ00004; ZFYVE5; faciogenital dysplasia 3; zinc finger FYVE domain-containing protein 5; MGC117260;
Product Background
Antigen Description
Promotes the formation of filopodia. May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape.
Pathway
Cell death signalling via NRAGE, NRIF and NADE, organism-specific biosystem; G alpha (12/13) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; NRAGE signals death through JNK, organism-specific biosystem; Regulation of actin cytoskeleton, organism-specific biosystem; Regulation of actin cytoskeleton, conserved biosystem; Rho GTPase cycle, organism-specific biosystem;
Citations
Publication ()
Have you cited DCABH-6073 in a publication?
Let us know and earn a reward for your research.
COA
Loading ......
