Specifications
Immunogen
antigen: VTVFENSRTP EAAPRGQRLE DVHHRPECRP PESPGPREKT NVGEAVGSEP RTVSRRYLNS LKNKLSSEAW RKSCQPVTLS GSGTQEPEKK IVQEL, corresponding to amino acids 16-110 of Human FGD2
Applications
Application Notes
ICC/IF: 1 - 4 μg/ml. IHC-P: 1/50 - 1/200.
Target
Alternative Names
FGD2; FYVE, RhoGEF and PH domain containing 2; ZFYVE4; FYVE, RhoGEF and PH domain-containing protein 2; FLJ00276 protein; FGD1 family, member 2; zinc finger FYVE domain-containing protein 4;
Product Background
Antigen Description
Activates CDC42, a member of the Ras-like family of Rho-and Rac proteins, by exchanging bound GDP for free GTP. Activates JNK1 via CDC42 but not RAC1. Binds to phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate.
Pathway
Cell death signalling via NRAGE, NRIF and NADE; GPCR downstream signaling; Rho GTPase cycle; Signaling by GPCR
Citations
Publication ()
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COA
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