Anti-FGD2 monoclonal antibody Made to order

Antibody Isotype

IgG

Species Reactivity

Mouse; Rat; Human

Immunogen

A synthetic peptide of human FGD2 is used for rabbit immunization.

Conjugate

Alternative Names

FGD2; FYVE, RhoGEF and PH domain containing 2; ZFYVE4; FYVE, RhoGEF and PH domain-containing protein 2; FLJ00276 protein; FGD1 family, member 2; zinc finger FYVE domain-containing protein 4;

Entrez Gene ID

UniProt ID

Antigen Description

FGD2 (FYVE, RhoGEF and PH domain containing 2) is a protein-coding gene. Diseases associated with FGD2 include aarskog-scott syndrome, and scott syndrome, and among its related super-pathways are NRAGE signals death through JNK and Signaling by GPCR. GO annotations related to this gene include phospholipid binding and Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is PLEKHF2. Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Activates JNK1 via CDC42 but not RAC1. Binds to phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate (By similarity)

Pathway

Cell death signalling via NRAGE, NRIF and NADE; G alpha (12/13) signalling events; GPCR downstream signaling; NRAGE signals death through JNK; Rho GTPase cycle; Signal Transduction; Signaling by GPCR; Signaling by Rho GTPases; Signalling by NGF; p75 NTR receptor-mediated signalling;