F-box/WD repeat-containing protein 7 is a protein that in humans is encoded by the FBXW7 gene. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. Mutations in this gene are detected in ovarian, breast and colorectal cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers.
Pathway
Adaptive Immune System; Antigen processing: Ubiquitination & Proteasome degradation; Association of TriC/CCT with target proteins during biosynthesis; Chaperonin-mediated protein folding; Class I MHC mediated antigen processing & presentation; Constitutiv
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