Anti-FBXW2 monoclonal antibody (DCABH-11541) Made to order

Rabbit anti-Human FBXW2 monoclonal antibody for WB, ELISA

View other FBXW2 antibodies

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human FBXW2 is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
FBXW2; F-box and WD repeat domain containing 2; F box and WD 40 domain protein 2; F-box/WD repeat-containing protein 2; FBW2; Fwd2
Entrez Gene ID
UniProt ID

Product Background


Gene summary
FBXW2 (F-Box And WD Repeat Domain Containing 2) is a Protein Coding gene. Diseases associated with FBXW2 include intestinal botulism and wound botulism. Among its related pathways are Transport to the Golgi and subsequent modification and Chaperonin-mediated protein folding. GO annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is TRAF7. F-box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid motif, the F box. Some F-box proteins have been shown to be critical for the ubiquitin-mediated degradation of cellular regulatory proteins. In fact, F-box proteins are one of the four subunits of ubiquitin protein ligases, called SCFs. SCF ligases bring ubiquitin conjugating enzymes to substrates that are specifically recruited by the different F-box proteins. Mammalian F-box proteins are classified into three groups based on the presence of either WD-40 repeats, leucine-rich repeats, or the presence or absence of other protein-protein interacting domains. This gene encodes the second identified member of the F-box gene family and contains multiple WD-40 repeats.
Antigen Description
F-box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid motif, the F box. Some F-box proteins have been shown to be critical for the ubiquitin-mediated degradation of cellular regulatory proteins. In fact, F-box proteins are one of the four subunits of ubiquitin protein ligases, called SCFs. SCF ligases bring ubiquitin conjugating enzymes to substrates that are specifically recruited by the different F-box proteins. Mammalian F-box proteins are classified into three groups based on the presence of either WD-40 repeats, leucine-rich repeats, or the presence or absence of other protein-protein interacting domains. This gene encodes the second identified member of the F-box gene family and contains multiple WD-40 repeats. Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. F-box/WD repeat-containing protein 2 is a protein that in humans is encoded by the FBXW2 gene. The function about FBXW2 antigen include ubiquitin-protein ligase activity.
Pathway
Association of TriC/CCT with target proteins during biosynthesis, organism-specific biosystem; Chaperonin-mediated protein folding, organism-specific biosystem; Metabolism of proteins, organism-specific biosystem; Protein folding, organism-specific biosystem; Wnt Signaling Pathway, organism-specific biosystem; Wnt Signaling Pathway and Pluripotency, organism-specific biosystem.

Citations


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We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


Chang, M; Rowland, CM; et al. A Large-Scale Rheumatoid Arthritis Genetic Study Identifies Association at Chromosome 9q33.2. PLOS GENETICS 4:-(2008).

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