Required for maintenance of chromosomal stability. Promotes accurate and efficient pairing of homologs during meiosis. Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing. May participate in S phase and G2 phase checkpoint activation upon DNA damage. Promotes BRCA2/FANCD1 loading onto damaged chromatin. May also be involved in B-cell immunoglobulin isotype switching.
Pathway
BARD1 signaling events; DNA Repair; Fanconi Anemia pathway; Fanconi anemia pathway; Regulation of the Fanconi anemia pathway; TNF-alpha/NF-kB Signaling Pathway;
Citations
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