Required for maintenance of chromosomal stability. Promotes accurate and efficient pairing of homologs during meiosis. Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing. May participate in S phase and G2 phase checkpoint activation upon DNA damage. Promotes BRCA2/FANCD1 loading onto damaged chromatin. May also be involved in B-cell immunoglobulin isotype switching.
Pathway
BARD1 signaling events; DNA Repair; Fanconi Anemia pathway; Fanconi anemia pathway; Regulation of the Fanconi anemia pathway; TNF-alpha/NF-kB Signaling Pathway;
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More
Citations
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Chang, H; Cui, XL; et al. Evaluation of Antibody Diluents for FANCD2 Immunohistochemistry with Breast Cancer Tissue. JOURNAL OF HISTOTECHNOLOGY 33:172-178(2010).
Donahue, SL; Lundberg, R; et al. Deficient regulation of DNA double-strand break repair in Fanconi anemia fibroblasts. JOURNAL OF BIOLOGICAL CHEMISTRY 278:29487-29495(2003).
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COA
Certificate of Analysis
