Specifications
Immunogen
Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human FANCD2 aa 1400 to the C-terminus (Cysteine residue). The exact sequence is proprietary. (Phospho specific peptide).Database link: Q9BXW9
Applications
Application Notes
WB: 1/1000 - 1/10000; Flow Cyt: 1/10 - 1/100.
Target
Alternative Names
FANCD2; Fanconi anemia, complementation group D2; FACD, FANCD; Fanconi anemia group D2 protein; FA D2; FAD; FA4; FACD; FAD2; FA-D2; FANCD; FLJ23826; DKFZp762A223;
Product Background
Antigen Description
Required for maintenance of chromosomal stability. Promotes accurate and efficient pairing of homologs during meiosis. Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing. May participate in S phase and G2 phase checkpoint activation upon DNA damage. Promotes BRCA2/FANCD1 loading onto damaged chromatin. May also be involved in B-cell immunoglobulin isotype switching.
Pathway
BARD1 signaling events, organism-specific biosystem; DNA Repair, organism-specific biosystem; Fanconi Anemia pathway, organism-specific biosystem; Fanconi anemia pathway, organism-specific biosystem; Fanconi anemia pathway, conserved biosystem; Regulation of the Fanconi anemia pathway, organism-specific biosystem; TNF-alpha/NF-kB Signaling Pathway, organism-specific biosystem;
Citations
Publication ()
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COA
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