Anti-FAF2 monoclonal antibody (DCABH-11487) Made to order

Rabbit anti-Human FAF2 monoclonal antibody for WB, ELISA

View other FAF2 antibodies

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human FAF2 is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
FAF2; Fas associated factor family member 2; UBX domain containing 8 , UBXD8; FAS-associated factor 2; ETEA; expressed in T cells and eosinophils in atopic dermatitis
Entrez Gene ID
UniProt ID

Product Background


Gene summary
FAF2 (Fas Associated Factor Family Member 2) is a Protein Coding gene. Diseases associated with FAF2 include atopic dermatitis and dermatitis. GO annotations related to this gene include ubiquitin protein ligase binding and lipase inhibitor activity. An important paralog of this gene is FAF1. The protein encoded by this gene is highly expressed in peripheral blood of patients with atopic dermatitis (AD), compared to normal individuals. It may play a role in regulating the resistance to apoptosis that is observed in T cells and eosinophils of AD patients.
Antigen Description
The protein encoded by this gene is highly expressed in peripheral blood of patients with atopic dermatitis (AD), compared to normal individuals. It may play a role in regulating the resistance to apoptosis that is observed in T cells and eosinophils of AD patients. Plays an important role in endoplasmic reticulum-associated degradation (ERAD) that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:18711132, PubMed:24215460). Involved in inhibition of lipid droplet degradation by binding to phospholipase PNPL2 and inhibiting its activity by promoting dissociation of PNPL2 from its endogenous activator, ABHD5 which inhibits the rate of triacylglycerol hydrolysis (PubMed:23297223). The function about FAF2 antigen include protein binding; ubiquitin binding; ubiquitin protein ligase binding.

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References


Wang, CW; Lee, SC; et al. The ubiquitin-like (UBX)-domain-containing protein Ubx2/Ubxd8 regulates lipid droplet homeostasis. JOURNAL OF CELL SCIENCE 125:2930-2939(2012).
Wahl, V; Brand, LH; et al. The FANTASTIC FOUR proteins influence shoot meristem size in Arabidopsis thaliana. BMC PLANT BIOLOGY 10:-(2010).

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