Rabbit Anti-Human FAF2 (a.a. 238-445) Polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Recombinant human FAF2 protein; Source: E. coli derived, PGEX-4T; Tag: GST; Domain: 238-445 aa of BC014001

Conjugate

Application Notes

WB: 1:5000-1:50000

General Notes

This product (Catalog No. DPABH-28464) is a rabbit-derived polyclonal antibody raised against human FAF2, targeting the amino acid region 238–445 of the protein. It has been affinity purified by Protein A. Protein ETEA (FAF2, or UBXD8) is a homolog to Fas-associated factor 1 (FAF1), which is involved in Fas-mediated apoptosis. ETEA protein directly interacts with and negatively regulates neurofibromin. ETEA contains both UBA and UBX domains and overexpression of ETEA downregulates neurofibromin in human cells. It may play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome. ETEA is highly expressed in peripheral blood of patients with atopic dermatitis (AD) compared to normal individuals, and may regulate the resistance to apoptosis that is observed in T cells and eosinophils of AD patients.
DPABH-28464 is suitable for use in Western blot (WB) (1:5,000–1:50,000) application.
DPABH-28464 is supplied as a liquid formulation in PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.

Alternative Names

ETEA; FAF2; FAS associated factor 2; KIAA0887; Protein ETEA; UBXD8; UBXN3B

Entrez Gene ID

UniProt ID