Anti-ESRP2 monoclonal antibody, clone 33D6.I8.B7

Clone

33D6.I8.B7

Species Reactivity

Mouse

Immunogen

Recombinant GST fusion protein corresponding to full length mouse Esrp2.

Conjugate

Alternative Names

ESRP2; epithelial splicing regulatory protein 2; RNA-binding protein 35B; RNA binding motif protein 35b; RNA-binding motif protein 35B; Rbm35b; 9530027K23Rik;

Entrez Gene ID

UniProt ID

Antigen Description

mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2.

Pathway

mRNA processing, organism-specific biosystem;