Anti-EXOSC7 monoclonal antibody, clone 3F6

Antibody Isotype

IgG1

Clone

3F6

Species Reactivity

Human

Immunogen

Recombinant full length Human EXOSC7 produced in HEK293T cells (NP_055819).

Conjugate

Application Notes

WB: 1/2000; IHC-P: 1/150; ICC/IF: 1/100;

Alternative Names

EXOSC7; exosome component 7; exosome complex component RRP42; EAP1; hRrp42p; KIAA0116; p8; RRP42; Rrp42p; exosome complex exonuclease RRP42; ribosomal RNA-processing protein 42; FLJ26543;

Entrez Gene ID

UniProt ID

Antigen Description

Non-catalytic component of the RNA exosome complex which has 3-> 5 exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding pervasive transcripts, such as anti-sense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3 untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes.

Pathway

Activation of Genes by ATF4, organism-specific biosystem; Deadenylation-dependent mRNA decay, organism-specific biosystem; Destabilization of mRNA by Butyrate Response Factor 1 (BRF1), organism-specific biosystem; Destabilization of mRNA by KSRP, organism-specific biosystem; Destabilization of mRNA by Tristetraprolin (TTP), organism-specific biosystem; Diabetes pathways, organism-specific biosystem; Disease, organism-specific biosystem;