General Notes
This product (Catalog No. DPABH-27114) is a rabbit-derived polyclonal antibody raised against human EXOSC4, targeting the amino acid region 1–245 of the protein. This antibody exhibits cross-reactivity with Human EXOSC4 from mouse and rat. It has been affinity purified by Protein A. EXOSC4, also named as RRP41 and SKI6, belongs to the RNase PH family. EXOSC4 is a novel component of the human exosome complex. EXOSC4 is the most important RNA processing machinery in maturation and degradation of RNA playing a major role in gene expression regulation (PMID: 29626590). EXOSC4 has 1 isoform with the molecular mass of 27 kDa. However, studies have shown that EXOSC4 can interact with EXOSC2 and EXOSC7, possibly form a complex with the molecular weight of 90 kDa (PMID: 25115889). Recently, EXOSC4 has been found to play important roles in tumorigcncsis and development including CRC (PMID: 33075373).
DPABH-27114 is suitable for use in Western blot (WB) (1:1,000–1:8,000), IHC (1:400–1:1,600), IF/ICC (1:50–1:500) applications.
DPABH-27114 is supplied as a liquid formulation in PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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