Anti-EXOSC2 monoclonal antibody, clone FQS24716

Antibody Isotype

IgG

Clone

FQS24716

Species Reactivity

Human

Immunogen

Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human RRP4 aa 1-100 (N terminal). The exact sequence is proprietary.Database link: Q13868

Conjugate

Application Notes

ICC/IF: 1/100 - 1/250; IP: 1/40 - 1/60; IHC-P: 1/50 - 1/100; WB: 1/10000 - 1/50000.

Alternative Names

EXOSC2; exosome component 2; exosome complex component RRP4; homolog of yeast RRP4 (ribosomal RNA processing 4); 3 5 exoribonuclease (RRP4); hRrp4p; p7; RRP4; Rrp4p; exosome complex exonuclease RRP4; ribosomal RNA-processing protein 4; homolog of yeast RR

Entrez Gene ID

UniProt ID

Antigen Description

The exosome, present in both the nucleus and cytoplasm of all eukaryotic cells, is a complex of 3-5 exoribonucleases containing at least nine core components. Recently, it has been demonstrated, mainly by analyses in yeast, that the nuclear exosome is essential for rRNA processing and sn(o)RNA biogenesis. Furthermore, it is involved in the degradation of improperly processed mRNAs. The cytoplasmic exosome participates in normal mRNA turnover and in the degradation of inherently instable mRNAs that contain AU-rich elements. Therefore, the exosome plays a key role in RNA metabolism.

Pathway

Activation of Genes by ATF4, organism-specific biosystem; Deadenylation-dependent mRNA decay, organism-specific biosystem; Destabilization of mRNA by Butyrate Response Factor 1 (BRF1), organism-specific biosystem; Destabilization of mRNA by KSRP, organism-specific biosystem; Destabilization of mRNA by Tristetraprolin (TTP), organism-specific biosystem; Diabetes pathways, organism-specific biosystem; Disease, organism-specific biosystem.