Specifications
Immunogen
Recombinant fragment, corresponding to amino acids 1-237 of Human RRP4 (AAH00747).
Applications
Application Notes
WB: 1/500 - 1/3,000; ICC/IF:1/100 - 1/500.
Target
Alternative Names
EXOSC2; exosome component 2; p7; RRP4; Rrp4p; hRrp4p; exosome complex component RRP4; exosome complex exonuclease RRP4; ribosomal RNA-processing protein 4; homolog of yeast RRP4 (ribosomal RNA processing 4), 3-5-exoribonuclease; homolog of yeast RRP4 (rib
Product Background
Antigen Description
The exosome, present in both the nucleus and cytoplasm of all eukaryotic cells, is a complex of 3-5 exoribonucleases containing at least nine core components. Recently, it has been demonstrated, mainly by analyses in yeast, that the nuclear exosome is essential for rRNA processing and sn(o)RNA biogenesis. Furthermore, it is involved in the degradation of improperly processed mRNAs. The cytoplasmic exosome participates in normal mRNA turnover and in the degradation of inherently instable mRNAs that contain AU-rich elements. Therefore, the exosome plays a key role in RNA metabolism.
Pathway
ATF4 activates genes; Deadenylation-dependent mRNA decay; Exosome, archaea; Exosome, eukaryotes
Citations
Publication ()
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COA
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