Anti-EXOC3 monoclonal antibody (CAB-3275MH)

Mouse anti-EXOC3 monoclonal antibody for ELISA, WB Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG2b
Clone
MAAG722
Species Reactivity
Human
Immunogen
EXOC3 (NP_009208, 646 a.a. - 746 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated

Applications


Application Notes
WB: 1:500-1000
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
EXOC3; exocyst complex component 3; SEC6 like 1 (S. cerevisiae) , SEC6L1; Sec6p; SEC6-like 1; Sec 6 homolog
Entrez Gene ID
UniProt ID

Product Background


Gene summary
EXOC3 (Exocyst Complex Component 3) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Stabilization and expansion of the E-cadherin adherens junction. GO annotations related to this gene include SNARE binding. An important paralog of this gene is TNFAIP2. The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity.
Antigen Description
The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity. Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Exocyst complex component 3 is a protein that in humans is encoded by the EXOC3 gene. The function about EXOC3 antigen include protein binding.
Pathway
Arf6 trafficking events, organism-specific biosystem; Diabetes pathways, organism-specific biosystem; Disease, organism-specific biosystem; Insulin Pathway, organism-specific biosystem; Insulin Synthesis and Processing, organism-specific biosystem; Stabilization and expansion of the E-cadherin adherens junction, organism-specific biosystem; Tight junction, organism-specific biosystem.

Citations


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References


Lee, HY; Lin, CI; et al. Lysophospholipids increase ICAM-1 expression in HUVEC through a G(i)- and NF-kappa B-dependent mechanism. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 287:C1657-C1666(2004).

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We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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