SEC6L1 (NP_009208, 646 a.a. ~ 745 a.a) partial recombinant protein with GST tag. The sequence is SGFGEDVDGYCDTIVAVAEVIKLTDPSLLYLEVSTLVSKYPDIRDDHIGALLAVRGDASR DMKQTIMETLEQGPAQASPSYVPLFKDIVVPSLNVAKLLK
The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity.
Pathway
Arf6 trafficking events; Insulin processing; Metabolism of proteins; Stabilization and expansion of the E-cadherin adherens junction
Citations
Publication ()
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