Anti-ETV1 (aa 148-257) polyclonal antibody

Species Reactivity

Human

Immunogen

ETV1 (NP_004947, 148 a.a. ~ 257 a.a) partial recombinant protein with GST tag. The sequence is LHHASPNSTHTPKPDRAFPAHLPPSQSIPDSSYPMDHRFRRQLSEPCNSFPPLPTMPREG RPMYQRQMSEPNIPFPPQGFKQEYHDPVYEHNTMVGSAASQSFPPPLMIK

Conjugate

Alternative Names

ETV1; ets variant 1; ER81; ETS translocation variant 1; ets variant gene 1; ets-related protein 81;

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a member of the ETS (E twenty-six) family of transcription factors. The ETS proteins regulate many target genes that modulate biological processes like cell growth, angiogenesis, migration, proliferation and differentiation. All ETS proteins contain an ETS DNA-binding domain that binds to DNA sequences containing the consensus 5-CGGA[AT]-3. The protein encoded by this gene contains a conserved short acidic transactivation domain (TAD) in the N-terminal region, in addition to the ETS DNA-binding domain in the C-terminal region. This gene is involved in chromosomal translocations, which result in multiple fusion proteins including EWS-ETV1 in Erwing sarcoma and at least 10 ETV1 partners (see PMID: 19657377, Table 1) in prostate cancer. In addition to chromosomal rearrangement, this gene is overexpressed in prostate cancer, melanoma and gastrointestinal stromal tumor. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.

Pathway

Transcriptional misregulation in cancer;