General Notes
This product (Catalog No. DPABH-22575) is a rabbit-derived polyclonal antibody raised against human ETHE1, targeting the amino acid region 23–254 of the protein. It has been affinity purified by Protein A. ETHE1 is a human gene that encodes a mitochondrial enzyme known as persulfide dioxygenase, which functions in the sulfide oxidation pathway to detoxify hydrogen sulfide (H₂S) by catalyzing the conversion of glutathione persulfide to sulfite. Located on chromosome 19q13.31, the gene consists of seven exons and produces a protein that is a homodimer containing a single iron atom, essential for its enzymatic activity in the mitochondrial matrix. This enzyme is ubiquitously expressed across tissues, with particularly high levels in the colon and duodenum, and plays a critical role in maintaining cellular energy production by preventing toxic accumulation of H₂S, which can inhibit cytochrome c oxidase (COX), a key component of the respiratory chain.
DPABH-22575 is suitable for use in ELISA (1:4,000–1:8,000), IHC (1:50–1:100), Western blot (WB) (1:1,000–1:4,000) applications.
DPABH-22575 is supplied as a liquid formulation in 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
COA
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