Specifications
Species Reactivity
Mouse; Rat; Human
Immunogen
Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human ETHE1 aa 200 to the C-terminus (Cysteine residue). The exact sequence is proprietary.Database link: O95571
Applications
Application Notes
WB: 1/1000 - 1/10000; IHC-P: 1/100 - 1/250.
Target
Alternative Names
ETHE1; ethylmalonic encephalopathy 1; protein ETHE1, mitochondrial; HSCO; YF13H12; ethylmalonic encephalopathy protein 1; hepatoma subtracted clone one protein;
Product Background
Antigen Description
Probably plays an important role in metabolic homeostasis in mitochondria. May function as a nuclear-cytoplasmic shuttling protein that binds transcription factor RELA/NFKB3 in the nucleus and exports it to the cytoplasm. Suppresses p53-induced apoptosis by preventing nuclear localization of RELA.
Pathway
Degradation of cysteine and homocysteine, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of amino acids and derivatives, organism-specific biosystem; Sulfide oxidation to sulfate, organism-specific biosystem; Sulfur amino acid metabolism, organism-specific biosystem;
Citations
Publication ()
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COA
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