ATP-dependent 3-5 DNA helicase, component of the core-TFIIH basal transcription factor, involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. Acts by opening DNA either around the RNA transcription start site or the DNA damage.
Pathway
Basal transcription factors; DNA Repair; Dual incision reaction in GG-NER; Epigenetic regulation of gene expression
Citations
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