Rabbit Anti-Human ERCC2 Polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human; Rat

Immunogen

Recombinant protein of human ERCC2.

Conjugate

Application Notes

WB: 1:500-1:2000
IF: 1:50-1:100

General Notes

This product (Catalog No. DPABH-16031) is a rabbit-derived polyclonal antibody raised against human ERCC2. This antibody exhibits cross-reactivity with ERCC2 from rat. It has been affinity purified by Protein A. The nucleotide excision repair pathway is a mechanism to repair damage to DNA. The protein encoded by this gene is involved in transcription-coupled nucleotide excision repair and is an integral member of the basal transcription factor BTF2/TFIIH complex. The gene product has ATP-dependent DNA helicase activity and belongs to the RAD3/XPD subfamily of helicases. Defects in this gene can result in three different disorders, the cancer-prone syndrome xeroderma pigmentosum complementation group D, trichothiodystrophy, and Cockayne syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
DPABH-16031 is suitable for use in Western blot (WB) (1:500–1:2,000), IF (immunofluorescence) (1:50–1:100) applications.
DPABH-16031 is supplied as a liquid formulation in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.

Alternative Names

EM9; TTD; XPD; COFS2; TFIIH

Entrez Gene ID

UniProt ID