The protein encoded by this gene is a nuclear encoded endonuclease that is localized in the mitochondrion. The encoded protein is widely distributed among animals and cleaves DNA at GC tracts. This protein is capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA. [provided by RefSeq, Jul 2008]
Pathway
Apoptosis; Apoptosis Modulation and Signaling
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More
Citations
Have you cited DPAB-L20415 in a publication? Let us know and earn a reward for your research.
Kim, YS; Bin Park, G; et al. Ligation of centrocyte/centroblast marker 1 on Epstein-Barr virus-transformed B lymphocytes induces cell death in a reactive oxygen species-dependent manner. HUMAN IMMUNOLOGY 67:795-807(2006).
Zanna, C; Ghelli, A; et al. Caspase-independent death of Leber's hereditary optic neuropathy cybrids is driven by energetic failure and mediated by AIF and Endonuclease G. APOPTOSIS 10:997-1007(2005).
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COA
Certificate of Analysis
