Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F]).
Pathway
Cap-dependent Translation Initiation; Eukaryotic Translation Initiation; GTP hydrolysis and joining of the 60S ribosomal subunit; Gene Expression; Metabolism of proteins; RNA transport;
Citations
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