Anti-eIF5 monoclonal antibody (DMABT-H13639)

Mouse anti-Human eIF5 monoclonal antibody for WB, IHC, IF, sELISA, ELISA Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
3F7-5D23
Species Reactivity
Human
Immunogen
EIF5 (AAH32866,2a.a. ~ 431 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated

Target


Alternative Names
EIF5; eukaryotic translation initiation factor 5; eIF-5; EIF-5A
Entrez Gene ID
UniProt ID

Product Background


Gene summary
EIF5 (Eukaryotic Translation Initiation Factor 5) is a Protein Coding gene. Among its related pathways are Gene Expression and Transport to the Golgi and subsequent modification. GO annotations related to this gene include poly(A) RNA binding and binding. Eukaryotic translation initiation factor-5 (EIF5) interacts with the 40S initiation complex to promote hydrolysis of bound GTP with concomitant joining of the 60S ribosomal subunit to the 40S initiation complex. The resulting functional 80S ribosomal initiation complex is then active in peptidyl transfer and chain elongations (summary by Si et al. , 1996 [PubMed 8663286]).
Antigen Description
Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S. mRNA. Met-tRNA[F]. eIF-2. GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S. Met-tRNA[F]). Eukaryotic translation initiation factor 5 is a protein that in humans is encoded by the EIF5 gene. 0The function about eIF5 antigen include GTP binding; GTPase activity; binding; nucleotide binding; translation factor activity, nucleic acid binding; translation initiation factor activity.
Pathway
Cap-dependent Translation Initiation, organism-specific biosystem; Eukaryotic Translation Initiation, organism-specific biosystem; GTP hydrolysis and joining of the 6S ribosomal subunit, organism-specific biosystem; Gene Expression, organism-specific biosystem; Metabolism of proteins, organism-specific biosystem; RNA transport, organism-specific biosystem; RNA transport, conserved biosystem.

Citations


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References


Chaudhuri, J; Chakrabarti, A; et al. Biochemical characterization of mammalian translation initiation factor 3 (eIF3) - Molecular cloning reveals that p110 subunit is the mammalian homologue of Saccharomyces cerevisiae protein Prt1. JOURNAL OF BIOLOGICAL CHEMISTRY 272:30975-30983(1997).
Hepat, R; Kim, Y; et al. A viral factor, CpBV15 alpha, interacts with a translation initiation factor, eIF2, to suppress host gene expression at a post-transcriptional level. JOURNAL OF INVERTEBRATE PATHOLOGY 114:34-41(2013).

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