Anti-eIF4E3 polyclonal antibody (DPABH-22470)
Rabbit anti-Human eIF4E3 (aa 175-224) polyclonal antibody for WB
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Synthetic peptide corresponding to a region within C terminal amino acids 175-224 (VQVWNVNASL VGEATVLEKI YELLPHITFK AVFYKPHEEH HAFEGGRGKH) of Human EIF4E3 (NP_001128123).
WB: 0.5 μg/ml.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.
EIF4E3; eukaryotic translation initiation factor 4E family member 3; eIF-4E3; eIF4E-3; eukaryotic translation initiation factor 4E type 3
EIF4E3 (Eukaryotic Translation Initiation Factor 4E Family Member 3) is a Protein Coding gene. Among its related pathways are Immune System and Interferon gamma signaling. GO annotations related to this gene include RNA binding and translation initiation factor activity. An important paralog of this gene is EIF4E1B. EIF4E3 belongs to the EIF4E family of translational initiation factors that interact with the 5-prime cap structure of mRNA and recruit mRNA to the ribosome (Joshi et al. , 2004 [PubMed 15153109]).
Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis. May act as an inhibitor of EIF4E1 activity. May act as an inhibitor of EIF4E1 activity (By similarity). Eukaryotic translation initiation factor 4E family member 3 is a protein that in humans is encoded by the EIF4E3 gene. 0The function about eIF4E3 antigen include translation initiation factor activity.
Antiviral mechanism by IFN-stimulated genes; ISG15 antiviral mechanism; Interferon Signaling.
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Cui, J; Han, SY; et al. c-Jun NH2-terminal kinase 2 alpha 2 promotes the tumorigenicity of human glioblastoma cells. CANCER RESEARCH 66:10024-10031(2006).
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