Anti-eIF4B monoclonal antibody, clone FQ3300Z

Antibody Isotype

IgG

Clone

FQ3300Z

Species Reactivity

Human

Immunogen

A synthetic peptide corresponding to residues on the C-terminus of human eIF4B.

Conjugate

Alternative Names

EIF4B; eukaryotic translation initiation factor 4B; EIF-4B; PRO1843;

Entrez Gene ID

UniProt ID

Antigen Description

Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F.

Pathway

Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, organism-specific biosystem; Cap-dependent Translation Initiation, organism-specific biosystem; Deadenylation of mRNA, organism-specific biosystem; Deadenylation-dependent mRNA decay, organism-specific biosystem; Eukaryotic Translation Initiation, organism-specific biosystem; GTP hydrolysis and joining of the 60S ribosomal subunit, organism-specific biosystem; Gene Expression, organism-specific biosystem;