Anti-eIF4B monoclonal antibody, clone 2G6

Antibody Isotype

IgG2b

Clone

2G6

Species Reactivity

Mouse; Human

Immunogen

Purified recombinant fragment of Human eIF4B expressed in E. Coli.

Conjugate

Application Notes

WB: 1/500 - 1/2000; ELISA: 1/10000; Flow Cyt: 1/200 - 1/400; ICC/IF: 1/200 - 1/1000;

Alternative Names

EIF4B; eukaryotic translation initiation factor 4B; EIF-4B; PRO1843;

Entrez Gene ID

UniProt ID

Antigen Description

Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F.

Pathway

Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, organism-specific biosystem; Cap-dependent Translation Initiation, organism-specific biosystem; Deadenylation of mRNA, organism-specific biosystem; Deadenylation-dependent mRNA decay, organism-specific biosystem; Eukaryotic Translation Initiation, organism-specific biosystem; GTP hydrolysis and joining of the 60S ribosomal subunit, organism-specific biosystem; Gene Expression, organism-specific biosystem;