Specifications
Species Reactivity
Mouse; Rat; Human; African green monkey
Immunogen
Recombinant fragment corresponding to Human eIF2A aa 448-576. Expressed in E. Coli.Sequence: PPALRNKPITNSKLHEEEPPQNMKPQSGNDKPLSKTALKNQRKHEAKKAA KQEARSDKSPDLAPTPAPQSTPRNTVSQSISGDPEIDKKIKNLKKKLKAI EQLKEQAATGKQLEKNQLEKIQKETALLQ Database link: Q9BY44
Applications
Application Notes
IHC-P: 1/200 - 1/1000; ELISA: 1/10000; WB: 1/500 - 1/2000; ICC/IF: 1/200 - 1/1000; Flow Cyt: 1/200 - 1/400.
Target
Alternative Names
EIF2A; eukaryotic translation initiation factor 2A, 65kDa; eukaryotic translation initiation factor 2A; EIF 2A; 65 kDa eukaryotic translation initiation factor 2A; CDA02; EIF-2A; MST089; MSTP004; MSTP089;
Product Background
Antigen Description
Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40 S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40 S subunits in a GTP-dependent manner. May act by impiging the expression of specific proteins.
Pathway
IL-6 Signaling Pathway, organism-specific biosystem; TGF-beta receptor signaling, organism-specific biosystem;
Citations
Publication ()
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COA
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