Anti-E1A monoclonal antibody (DMABT-H21000)

Mouse anti-E1A monoclonal antibody for IP, WB, ICC Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG2a
Clone
N84
Species Reactivity
N/A
Immunogen
trpE-Ad2 E1A fusion protein isolated from E. coli
Conjugate
Unconjugated

Target


Alternative Names
Control protein E1A antibody; E1A antibody; Mouse Anti-E1A Monoclonal Antibody; Anti-E1A Monoclonal Antibody; E1A Monoclonal Antibody Mouse Anti-E1A MAb; Anti-E1A MAb

Product Background


Antigen Description
The early region (E1) of the adenovirus genome, responsible for transforming activity, is localized within the left most 11% of the viral genome and consists of two transcriptional units E1A and E1B. E1A is sufficient for partial transformation and immortalization of primary cells. E1A gene products are necessary for normal levels of transcription of the other early regions of the adenovirus genome during productive infection and are able to either activate or repress the transcription of specific cellular genes. E1A forms specific complexes with cellular proteins including p105 causing inhibition of the cell cycle inducing arresting function of p105.

Citations


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References


NAKANISHI, Y; KIHARA, K; et al. DIRECT EFFECT OF BASIC FIBROBLAST GROWTH-FACTOR ON GENE-TRANSCRIPTION IN A CELL-FREE SYSTEM. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 89:5216-5220(1992).
Bulhak-Koziol, V; Zdrodowska-Stefanow, B; et al. Prevalence of Chlamydia trachomatis infection in women with cervical lesions. ADVANCES IN MEDICAL SCIENCES 52:179-181(2007).

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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