Anti-E1A monoclonal antibody (DMABT-H21000)
Mouse anti-E1A monoclonal antibody for IP, WB, ICC
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trpE-Ad2 E1A fusion protein isolated from E. coli
Control protein E1A antibody; E1A antibody; Mouse Anti-E1A Monoclonal Antibody; Anti-E1A Monoclonal Antibody; E1A Monoclonal Antibody Mouse Anti-E1A MAb; Anti-E1A MAb
The early region (E1) of the adenovirus genome, responsible for transforming activity, is localized within the left most 11% of the viral genome and consists of two transcriptional units E1A and E1B. E1A is sufficient for partial transformation and immortalization of primary cells. E1A gene products are necessary for normal levels of transcription of the other early regions of the adenovirus genome during productive infection and are able to either activate or repress the transcription of specific cellular genes. E1A forms specific complexes with cellular proteins including p105 causing inhibition of the cell cycle inducing arresting function of p105.
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BROWN, CR; DOXSEY, SJ; et al. BOTH VIRAL (ADENOVIRUS E1B) AND CELLULAR (HSP-70, P53) COMPONENTS INTERACT WITH CENTROSOMES. JOURNAL OF CELLULAR PHYSIOLOGY 160:47-60(1994).
ARSENAULT, H; WEBER, JM; et al. MAPPING OF THE MAB73 EPITOPE ON AD2 E1A PROTEINS WITH RANDOM PEPTIDE LIBRARIES AND DELETION MUTANTS. FEMS MICROBIOLOGY LETTERS 114:37-40(1993).
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.