Anti-AB monoclonal antibody (DMAB9033MD)

Mouse anti-drosophila AB monoclonal antibody for IHC Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
Abrupt
Species Reactivity
drosophila
Immunogen
Abrupt from Drosophila melanogaster.
Conjugate
Unconjugated

Target


Alternative Names
ab; abrupt; Ab; B2149; CG4807; clu
Entrez Gene ID
UniProt ID

Product Background


Gene summary
STK26 (Serine/Threonine Protein Kinase 26) is a Protein Coding gene. Among its related pathways are Apoptotic cleavage of cellular proteins and LKB1 signaling events. GO annotations related to this gene include protein homodimerization activity and transferase activity, transferring phosphorus-containing groups. An important paralog of this gene is STK4. The product of this gene is a member of the GCK group III family of kinases, which are a subset of the Ste20-like kinases. The encoded protein contains an amino-terminal kinase domain, and a carboxy-terminal regulatory domain that mediates homodimerization. The protein kinase localizes to the Golgi apparatus and is specifically activated by binding to the Golgi matrix protein GM130. It is also cleaved by caspase-3 in vitro, and may function in the apoptotic pathway. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.
Antigen Description
Mediator of cell growth. Modulates apoptosis. Serine/threonine protein kinase MST4, also known as mammalian STE20-like protein kinase 4 (MST-4), is a protein that in humans is encoded by the MST4 gene. The product of this gene is a member of the GCK group III family of kinases, which are a subset of the Ste20-like kinases. The encoded protein contains an amino-terminal kinase domain, and a carboxy-terminal regulatory domain that mediates homodimerization. The protein kinase localizes to the Golgi apparatus and is specifically activated by binding to the Golgi matrix protein GM130. It is also cleaved by caspase-3 in vitro, and may function in the apoptotic pathway. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. The function about MST4 antigen include sequence-specific DNA binding transcription factor activity; zinc ion binding.

Citations


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References


Ana-Sosa-Batiz, F; Johnston, APR; et al. HIV-specific antibody-dependent phagocytosis matures during HIV infection. IMMUNOLOGY AND CELL BIOLOGY 92:679-687(2014).
Janbaz, AH; Lindstrom, M; et al. Intermediate Filaments in the Human Extraocular Muscles. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 55:5151-5159(2014).

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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