Anti-Dipyrone polyclonal antibody

Background: Acetaminophen (paracetamol) and dipyrone (metamizole) are regularly used in perioperative medicine. The evidence regarding their risk/benefit ratio especially in the critical care environment is insufficient. Accordingly, the relevance of the potential side effects of dipyrone and acetaminophen in critically ill patients is unclear. Little is also known about the practical aspects of their use in the critical care environment with regard to their indications and contraindications. Thus, the aim of this study was to investigate the indications and contraindications for the use of dipyrone and acetaminophen in German intensive care units. Method: We conducted this survey from July to August 2016 using an online questionnaire. We sent this questionnaire to physicians who work in intensive care units at 16 German university hospitals. Results: 344 questionnaires were fully answered and subsequently analysed. Our data show that most physicians use dipyrone or paracetamol to treat fever and pain in the critical care environment. As far as the the indication for treatment with these medications was concerned, we found that the threshold for fever treatment varies between 37.5 degrees C and 40 degrees C. We also found a profound deviations from the contraindications stated in the respective SPCs for treatment with dipyrone and paracetamol. Conclusions: Taken together, dipyrone and paracetamol are regularly used for the treatment of fever and pain in the intensive care units in our questioned collective. However, there is a remarkable variance with regard to indications and contraindications. We interpret this variance as sign for the lack of treatment data in the critical care environment of these medications. Accordingly, we think further studies with a focus on the use of these substances are urgently needed.

Sickness behavior appears to be the expression of a central motivational state that reorganizes the organism's priorities to cope with infectious pathogens. To evaluate the effect of dipyrone in lipopolysaccharide (LPS)-induced sickness behavior, mice were subjected to the forced swim test (FST), tail suspension test (TST), dark-light box test, open field test, sucrose preference intake test and food intake test. LPS administration increased the immobility time in the TST, increased the time spent floating in the FST, and depressed locomotor activity in the open field test. Treatment with LPS decreased the total number of transitions made between the dark and light compartments of the apparatus and induced anhedonia and anorexia. Pre-treatment with dipyrone (10, 50, or 200 mg/kg) attenuated behavioral changes induced by LPS in the FST, TST, open field and light-dark box tests. In addition, dipyrone prevented anhedonia and anorexia in mice challenged with LPS. Considering that dipyrone attenuates LPS-induced behavioral changes, it is proposed that LPS-induced sickness behavior is dependent on the COX pathway. (C) 2012 Elsevier Ireland Ltd. All rights reserved.