Anti-DVL2 monoclonal antibody (DCABH-11345) Made to order

Rabbit anti-Human DVL2 monoclonal antibody for WB, ELISA

View other DVL2 antibodies

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human DVL2 is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
DVL2; dishevelled, dsh homolog 2 (Drosophila); dishevelled 2 (homologous to Drosophila dsh); segment polarity protein dishevelled homolog DVL-2; DSH homolog 2; dishevelled-2
Entrez Gene ID
UniProt ID

Product Background


Gene summary
DVL2 (Dishevelled Segment Polarity Protein 2) is a Protein Coding gene. Diseases associated with DVL2 include neural tube defects and conotruncal heart malformations. Among its related pathways are Signaling by GPCR and Signaling by Rho GTPases. GO annotations related to this gene include identical protein binding and protein self-association. An important paralog of this gene is DIXDC1. This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans.
Antigen Description
This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans. Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes (By similarity). Segment polarity protein dishevelled homolog DVL-2 is a protein that in humans is encoded by the DVL2 gene. 0The function about DVL2 antigen include frizzled binding; identical protein binding; protein binding; protein domain specific binding; protein self-association; signal transducer activity.
Pathway
Basal cell carcinoma, organism-specific biosystem; Basal cell carcinoma, conserved biosystem; Canonical Wnt signaling pathway, organism-specific biosystem; DNA damage response (only ATM dependent), organism-specific biosystem; HTLV-I infection, organism-specific biosystem; HTLV-I infection, conserved biosystem; Melanogenesis, organism-specific biosystem.

Citations


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We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


Gonzalez-Sancho, JM; Greer, YE; et al. Functional Consequences of Wnt-induced Dishevelled 2 Phosphorylation in Canonical and Noncanonical Wnt Signaling. JOURNAL OF BIOLOGICAL CHEMISTRY 288:9428-9437(2013).
Lee, YN; Gao, Y; et al. Differential mediation of the Wnt canonical pathway by mammalian Dishevelleds-1,-2, and-3. CELLULAR SIGNALLING 20:443-452(2008).

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