Anti-DUSP10 (full length) polyclonal antibody

Species Reactivity

Human

Immunogen

DUSP10 (AAH20608, 1 a.a. ~ 140 a.a) full-length recombinant protein with GST tag. The sequence is MQRLNIGYVINVTTHLPLYHYEKGLFNYKRLPATDSNKQNLRQYFEEAFEFIEEAHQCGK GLLIHCQAGVSRSATIVIAYLMKHTRMTMTDAYKFVKGKRPIISPNLNFMGQLLEFEEDL NNGVTPRILTPKLMGVETVV

Conjugate

Alternative Names

DUSP10; dual specificity phosphatase 10; MKP5; MKP-5; dual specificity protein phosphatase 10; map kinase phosphatase 5; dual specificity phosphatase MKP-5; serine/threonine specific protein phosphatase; mitogen-activated protein kinase phosphatase 5;

Entrez Gene ID

UniProt ID

Antigen Description

Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAP kinase superfamily, which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAP kinases, different tissue distribution and subcellular localization, and different modes of expression induction by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK. Alternative splicing results in multiple transcript variants.

Pathway

ATF-2 transcription factor network; MAPK signaling pathway;