Anti-DSG3 monoclonal antibody, clone 8C0

Antibody Isotype

IgG1

Clone

8C0

Species Reactivity

Human

Immunogen

Recombinant protein of Human Desmoglein 3 extracellular domain.

Conjugate

Application Notes

WB: 0.1 - 1 μg/ml; IP: 2 - 5 μg/ml; ELISA: 0.01 - 0.1 μg/ml; IHC-P: 2 - 5 μg/ml; Flow Cyt: 1/1000 - 1/10000;

Alternative Names

DSG3; desmoglein 3; desmoglein 3 (pemphigus vulgaris antigen); desmoglein-3; CDHF6; pemphigus vulgaris antigen; cadherin family member 6; 130-kD pemphigus vulgaris antigen; 130 kDa pemphigus vulgaris antigen; PVA; DKFZp686P23184;

Entrez Gene ID

UniProt ID

Antigen Description

Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. Desmoglein 3 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. This protein has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus vulgaris.

Pathway

Apoptosis, organism-specific biosystem; Apoptotic cleavage of cell adhesionproteins, organism-specific biosystem; Apoptotic cleavage of cellular proteins, organism-specific biosystem; Apoptotic executionphase, organism-specific biosystem;