Anti-DOK6 (aa 96-277) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Mouse

Immunogen

Recombinant fragment, corresponding to a region within amino acids 96-277 of Human DOK6 (Q6PKX4).

Conjugate

Application Notes

WB: 1/500 - 1/3000.

Alternative Names

DOK6; docking protein 6; docking protein 5 like; DOK5L; HsT3226; MGC20785; downstream of tyrosine kinase 6; DOK5L;

Entrez Gene ID

UniProt ID

Antigen Description

DOK6 (docking protein 6) is a novel member of the DOK4/5 subclass of the p62 DOK family of intracellular adaptor molecules. DOK6 is highly expressed in the developing central nervous system and is co expressed with Ret in several locations, including sympathetic, sensory, and parasympathetic ganglia, as well as in the ureteric buds of the developing kidneys. Pull down assays using the DOK6 phosphotyrosine binding (PTB) domain and GDNF activated Ret indicate that DOK6 binds to the phosphorylated Ret Tyr(1062) residue. Moreover, ligand activation of Ret resulted in phosphorylation of tyrosine residue(s) located within the unique C terminus of DOK6 predominantly through a Src dependent mechanism, indicating that DOK6 is a substrate of the Ret Src signaling pathway.

Pathway

Signaling events regulated by Ret tyrosine kinase;