Anti-DNM1L (C-terminal) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Mouse; Rat; Human

Immunogen

Recombinant fragment within Human DRP1 (C terminal). The exact sequence is proprietary. 300 amino acids within C terminal end.Database link: O00429

Conjugate

Application Notes

WB: 1/500 - 1/2000; IHC-P: 1/50 - 1/200;

Alternative Names

DNM1L; dynamin 1-like; DLP1; DRP1; DVLP; EMPF; DYMPLE; HDYNIV; dynamin-1-like protein; dynamin-like protein 4; dynamin-like protein IV; Dnm1p/Vps1p-like protein; dynamin-related protein 1; dynamin family member proline-rich carboxyl-terminal domain less;

Entrez Gene ID

UniProt ID

Antigen Description

Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into ring-like structures which wrap around the scission site to constict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism. Required for normal brain development. Facilitates developmentally-regulated apoptosis during neural tube development. Required for a normal rate of cytochrome c release and caspase activation during apoptosis. Also required for mitochondrial fission during mitosis. May be involved in vesicle transport.Isoform 1 and isoform 4 inhibit peroxisomal division when overexpressed.

Pathway

Apoptosis; Synaptic Vesicle Pathway; TNF signaling pathway;