Anti-DNM1L monoclonal antibody, clone 3F8

Antibody Isotype

IgG2b

Clone

3F8

Species Reactivity

Mouse; Rat; Human; Monkey

Immunogen

Recombinant full length Human DNM1L (amino acids 1-736) produced in HEK293T cells.

Conjugate

Application Notes

WB: 1/200 - 1/4000; IHC-P: 1/150; Flow Cyt: 1/100;

Alternative Names

DNM1L; dynamin 1-like; dynamin-1-like protein; DRP1; DVLP; DYMPLE; HDYNIV; VPS1; dynamin-like protein 4; dynamin-like protein IV; Dnm1p/Vps1p-like protein; dynamin-related protein 1; dynamin family member proline-rich carboxyl-terminal domain less; DLP1;

Entrez Gene ID

UniProt ID

Antigen Description

Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into ring-like structures which wrap around the scission site to constict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism. Required for normal brain development. Facilitates developmentally-regulated apoptosis during neural tube development. Required for a normal rate of cytochrome c release and caspase activation during apoptosis. Also required for mitochondrial fission during mitosis. May be involved in vesicle transport.Isoform 1 and isoform 4 inhibit peroxisomal division when overexpressed.

Pathway

Apoptosis, organism-specific biosystem; Apoptotic executionphase, organism-specific biosystem; Bacterial invasion of epithelial cells, organism-specific biosystem; Bacterial invasion of epithelial cells, conserved biosystem; Endocrine and other factor-regulated calcium reabsorption, organism-specific biosystem; Endocrine and other factor-regulated calcium reabsorption, conserved biosystem; Endocytosis, organism-specific biosystem;