Anti-DNASE2 monoclonal antibody (DCABH-11307) Made to order

Rabbit anti-Human DNASE2 monoclonal antibody for WB, ELISA

View other DNASE2 antibodies

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human DNASE2 is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
DNASE2; deoxyribonuclease II, lysosomal; DNL, DNL2; deoxyribonuclease-2-alpha; R31240_2; acid DNase
Entrez Gene ID
UniProt ID

Product Background


Gene summary
DNASE2 (Deoxyribonuclease II, Lysosomal) is a Protein Coding gene. Diseases associated with DNASE2 include calcific tendinitis and tenosynovitis. Among its related pathways are Lysosome and Vesicle-mediated transport. GO annotations related to this gene include endodeoxyribonuclease activity and deoxyribonuclease II activity. An important paralog of this gene is DNASE2B. This gene encodes a member of the DNase family. The protein, located in the lysosome, hydrolyzes DNA under acidic conditions and mediates the breakdown of DNA during erythropoiesis and apoptosis. Two codominant alleles have been characterized, DNASE2*L (low activity) and DNASE2*H (high activity), that differ at one nucleotide in the promoter region. The DNASE2*H allele is represented in this record.
Antigen Description
This gene encodes a member of the DNase family. The protein, located in the lysosome, hydrolyzes DNA under acidic conditions and mediates the breakdown of DNA during erythropoiesis and apoptosis. Two codominant alleles have been characterized, DNASE2*L (low activity) and DNASE2*H (high activity), that differ at one nucleotide in the promoter region. The DNASE2*H allele is represented in this record. Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Plays a major role in the degradation of nuclear DNA in cellular apoptosis during development. Necessary for proper fetal development and for definitive erythropoiesis in fetal liver, where it degrades nuclear DNA expelled from erythroid precursor cells. The function about DNASE2 antigen include DNA binding; deoxyribonuclease II activity; endodeoxyribonuclease activity; hydrolase activity.
Pathway
Clathrin derived vesicle budding, organism-specific biosystem; Lysosome, organism-specific biosystem; Lysosome, conserved biosystem; Lysosome Vesicle Biogenesis, organism-specific biosystem; Membrane Trafficking, organism-specific biosystem; trans-Golgi Network Vesicle Budding, organism-specific biosystem.

Citations


Have you cited DCABH-11307 in a publication? Let us know and earn a reward for your research.

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

Customer Reviews


Write a review, share your experiences with others and get rewarded !
Product Name Cat. No. Applications Host Species Datasheet Price Add to Basket

References


Yasuda, T; Takeshita, H; et al. Molecular cloning of the cDNA encoding human deoxyribonuclease II. JOURNAL OF BIOLOGICAL CHEMISTRY 273:2610-2616(1998).
Rossol, M; Pierer, M; et al. Homozygosity for DNASE2 single nucleotide polymorphisms in the 5 '-regulatory region is associated with rheumatoid arthritis. ANNALS OF THE RHEUMATIC DISEASES 68:1498-1503(2009).

Online Inquiry

Name:
Phone: *
E-mail Address: *
Service & Products Interested: *
Project Description:
Verification Code: * Please input "diagnostics" as verification code.

Online Inquiry

  Interested in larger quantities ? request a quote!
  Protocol may be improved. Please feel free to contact us to obtain the latest version.!

Ordering Information

Payment methods we support:
Invoice / Purchase Order
Credit card

OUR PROMISE TO YOU Guaranteed product quality expert customer support

Inquiry Basket