Synthetic peptide conjugated to KLH derived from within residues 250 - 350 of Human DNAJC3.
Conjugate
Unconjugated
Applications
Application Notes
ICC/IF: 1 μg/ml; WB: 1 μg/ml.
Target
Alternative Names
DNAJC3; DnaJ (Hsp40) homolog, subfamily C, member 3; PRKRI; dnaJ homolog subfamily C member 3; HP58; P58; P58IPK; protein kinase inhibitor p58; protein kinase inhibitor of 58 kDa; interferon-induced, double-stranded RNA-activated protein kinase inhibitor;
Involved in the unfolded protein response (UPR) during ER stress. Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity.
Pathway
Activation of Chaperone Genes by XBP1(S); Activation of Chaperones by IRE1alpha; Diabetes pathways; Disease; Influenza A; Influenza Infection;
Citations
Publication ()
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COA
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