Oriented attachment of V-NAR proteins, via site-selective modification, on PLGA-PEG nanoparticles enhances nanoconjugate performance
CHEMICAL COMMUNICATIONS
Authors: Nogueira, Joao C. F.; Greene, Michelle K.; Richards, Daniel A.; Furby, Alexander O.; Steven, John; Porter, Andrew; Barelle, Caroline; Scott, Christopher J.; Chudasama, Vijay
Abstract
Herein we report the construction of a nanoparticle-based drug delivery system which targets a key regulator in tumour angiogenesis. We exploit a Variable New Antigen Receptor (V-NAR) domain, conjugated using site-specific chemistry, to direct poly lactic acid-co-glycolic acid-polyethylene glycol (PLGA-PEG) nanoparticles to delta like canonical Notch ligand 4 (DLL4). The importance of site-specific chemistry is demonstrated.
COA
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