Specifications
Immunogen
Recombinant full length protein corresponding to Human Smac aa 56-239. Sequence represents that of mature protein. Purified from E.coli. (NP_063940)Sequence: AVPIA QKSEPHSLSS EALMRRAVSL VTDSTSTFLS QTTYALIEAI TEYTKAVYTL TSLYRQYTSL LGKMNSEEED EVWQVIIGAR AEM
Applications
Application Notes
ELISA: 1/3000; WB: 1/3000.
Target
Alternative Names
DIABLO; diablo, IAP-binding mitochondrial protein; diablo homolog, mitochondrial; DFNA64; DIABLO S; FLJ10537; FLJ25049; second mitochondria derived activator of caspase; SMAC; 0610041G12Rik; mitochondrial Smac protein; direct IAP-binding protein with low
Product Background
Antigen Description
Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP).
Pathway
Apoptosis, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptotic factor-mediated response, organism-specific biosystem; Caspase cascade in apoptosis, organism-specific biosystem; Intrinsic Pathway for Apoptosis, organism-specific biosystem; Release of apoptotic factors from the mitochondria, organism-specific biosystem; SMAC binds to IAPs, organism-specific biosystem;
Citations
Publication ()
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COA
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