Anti-DDX39B (aa 329-428) polyclonal antibody

Species Reactivity

Human

Immunogen

BAT1 (NP_004631, 329 a.a. ~ 428 a.a) partial recombinant protein with GST tag. The sequence is RYQQFKDFQRRILVATNLFGRGMDIERVNIAFNYDMPEDSDTYLHRVARAGRFGTKGLAI TFVSDENDAKILNDVQDRFEVNISELPDEIDISSYIEQTR

Conjugate

Alternative Names

DDX39B; DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B; BAT1; UAP56; D6S81E; spliceosome RNA helicase DDX39B; spliceosome RNA helicase BAT1; ATP-dependent RNA helicase p47; 56 kDa U2AF65-associated protein; nuclear RNA helicase (DEAD family); HLA-B-associated

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a member of the DEAD box family of RNA-dependent ATPases that mediate ATP hydrolysis during pre-mRNA splicing. The encoded protein is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. This gene belongs to a cluster of genes localized in the vicinity of the genes encoding tumor necrosis factor alpha and tumor necrosis factor beta. These genes are all within the human major histocompatibility complex class III region. Mutations in this gene may be associated with rheumatoid arthritis. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on both chromosomes 6 and 11. Read-through transcription also occurs between this gene and the upstream ATP6V1G2 (ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2) gene.

Pathway

Exon junction complex (EJC); Influenza A; RNA transport; Spliceosome