General Notes
This product (Catalog No. DPABH-23388) is a rabbit-derived polyclonal antibody raised against human DDX18, targeting the amino acid region 7–165 of the protein. This antibody exhibits cross-reactivity with Human DDX18 from mouse. It has been affinity purified by Protein A. DDX18 (DEAD-Box Helicase 18) is a member of the DEAD-box family of RNA helicases, which are ATP-dependent enzymes involved in remodeling RNA secondary structures and ribonucleoprotein complexes. It is primarily localized in the nucleus and nucleolus, where it plays an important role in ribosome biogenesis, particularly in the processing and maturation of pre-ribosomal RNA. By facilitating proper assembly and structural rearrangement of ribosomal subunits, DDX18 contributes to efficient protein synthesis and overall cellular growth. Like other DEAD-box proteins, it is also implicated in broader aspects of RNA metabolism, including RNA splicing and transport. Expression of DDX18 is generally ubiquitous, consistent with its fundamental role in core cellular processes. Dysregulation of RNA helicases, including DDX18, has been associated with altered ribosome function and may contribute to cancer and other proliferative disorders, although its specific disease mechanisms remain under investigation.
DPABH-23388 is suitable for use in Western blot (WB) (1:1,000–1:4,000), IP (0.5-4.0 μg for 1.0-3.0 mg of total protein lysate), IF/ICC (1:200–1:800) applications.
DPABH-23388 is supplied as a liquid formulation in PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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